Comutagenesis-V: rapid conversion of 2-hydroxylamino-3-methylpyridine to 2-amino-3-methylpyridine by a hepatic S9 preparation

Gorrod J., ALTUNTAŞ T.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, vol.22, no.4, pp.341-344, 1997 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 4
  • Publication Date: 1997
  • Doi Number: 10.1007/bf03190968
  • Journal Name: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.341-344
  • Keywords: in vitro metabolism, 2-hydroxylamino-3-methylpyridine, 2-amino-3-methylpyridine, enzymatic reduction, METABOLISM
  • Ankara University Affiliated: No

Abstract

The in vitro metabolism of 2-hydroxylamino-3-methylpyridine has been investigated using arochlor 1254 pretreated rat S9 mixtures. 2-Hydroxylamino-3-methylpyridine is rapidly converted to the parent amine 2-amino-3-methylpyridine. No further oxidation products of 2-hydroxylamino-3-methylpyridine (i.e., nitroso or nitro) were detected under the HPLC conditions used. This observation may explain our previous findings on the in vitro metabolism of 2-amino-3-methylpyridine where no hydroxylamino metabolite was detected.