Importance of NOD2/CARD15 gene variants for susceptibility to and outcome of sepsis in Turkish children

TEKİN D., Dalgic N., Kayaalti Z., Soylemezoglu T., Diler B., Kutlubay B. I.

PEDIATRIC CRITICAL CARE MEDICINE, cilt.13, sa.2, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1097/pcc.0b013e3182191c2e
  • Dergi Adı: PEDIATRIC CRITICAL CARE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: sepsis, childhood, NOD2/CARD15 gene, polymorphism, mortality, Pediatric Risk of Mortality III score, CROHNS-DISEASE, MUTATIONS, NOD2, INNATE, DIPEPTIDE, MORTALITY, POLYMORPHISMS, RECOGNITION, IMMUNITY
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Severe sepsis remains a leading cause of morbidity and mortality in children. Given the link to pathogenesis, polymorphisms in genes involved in infection and inflammation may influence the outcomes in patients with sepsis and septic shock. The role of mutations within the innate immunity receptor NOD2/CARD15 has recently been demonstrated as a risk factor for bacteremia and mortality in adult patients with sepsis. The aim of this study was to evaluate the role of mutations of the NOD2/CARD15 gene in pediatric patients with sepsis.