Secondary acute leukemia following mitoxantrone-based high-dose chemotherapy for primary breast cancer patients

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Kroger N., Damon L., Zander A., Wandt H., Derigs G., Ferrante P., ...Daha Fazla

BONE MARROW TRANSPLANTATION, cilt.32, sa.12, ss.1153-1157, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 12
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1038/sj.bmt.1704291
  • Dergi Adı: BONE MARROW TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1153-1157
  • Anahtar Kelimeler: high-dose chemotherapy, adjuvant therapy, breast cancer, mitoxantrone, secondary AML, ACUTE MYELOID-LEUKEMIA, STEM-CELL TRANSPLANTATION, THERAPY-RELATED LEUKEMIA, ACUTE PROMYELOCYTIC LEUKEMIA, BONE-MARROW TRANSPLANTATION, ACUTE MYELOGENOUS LEUKEMIA, MYELODYSPLASTIC SYNDROME, ADJUVANT CHEMOTHERAPY, DNA-TOPOISOMERASE, RISK
  • Ankara Üniversitesi Adresli: Evet

Özet

The incidence of secondary myelodysplasia/acute myeloid leukemia (AML) was retrospectively assessed in an international joint study in 305 node-positive breast cancer patients, who received mitoxantrone-based high-dose chemotherapy (HDCT) followed by autologous stem cell support as adjuvant therapy. The median age of the patients was 57 years (range 22-67). In all, 268 patients received peripheral blood stem cells, and 47 patients received autologous bone marrow. After a median follow-up of 57 months (range 10-125), three cases of secondary AML (sAML) were observed, resulting in a cumulative incidence of 0.94%. One case of sAML developed 18 months after HDCT (FAB M3) The karyotype was translocation 15; 17 and, after induction therapy, the patient underwent autologous stem cell transplantation, and is in complete remission (CR) of both breast cancer and AML. The second patient developed AML (FAB M4eo with inversion 16) 5 months after HDCT. This patient achieved CR after induction therapy, but died of infectious complication. A third patient developed AML (FAB M4) 6 months after HDCT. She achieved CR after induction therapy, but relapsed and expired 28 months after diagnosis of AML. sAML after mitoxantrone-based HDCT is a possible, but rare complication in breast cancer patients.