Spectral Continuous Wavelet Transform for the Simultaneous Spectrophotometric Analysis of a Combined Pharmaceutical Formulation

DİNÇ E., BALEANU D.

REVISTA DE CHIMIE, cilt.60, sa.8, ss.741-744, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 8
  • Basım Tarihi: 2009
  • Dergi Adı: REVISTA DE CHIMIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.741-744
  • Anahtar Kelimeler: continuous wavelet analysis, binary mixture, trimethoprim, sulphamethoxazole, tablets, SIMULTANEOUS QUANTITATIVE-ANALYSIS, BINARY-MIXTURE, CHEMOMETRIC METHODS, PYRIDOXINE HCL, THIAMINE HCL, HYDROCHLOROTHIAZIDE, TELMISARTAN, MULTIDETERMINATION, TABLETS
  • Ankara Üniversitesi Adresli: Evet

Özet

Continuous wavelet transform (CWT) combined with zero crossing technique was proposed for the simultaneous spectrophotometric determination of telmisartan (TMS) and hydrochlorothiazide (HCT) in their binary mixtures without using a chemical pretreatment. This new hybrid analytical approach is based on the application of the CWT method to the absorption spectra of the analytes and their samples. In the signal analysis, Gaussian (GAUS3) with order 3 and BiorSplines (BIOR1.2) with 1.2 order were found to be suitable for the quantitative spectral resolution of TMS and HCT in samples. These hybrid approaches were named as GAUS3-CWT and BIOR1.2-CWT The validation of the CWT signal processing methods was carried out by using various binary mixtures of the analytes. The amounts of TMS and HCT in tablets were successfully determined by using the proposed GAUS3-CWT and BIOR1.2-CWT tools.