The-137G/C Polymorphism in Interleukin-18 Gene Promoter Contributes to Chronic Lymphocytic and Chronic Myelogenous Leukemia Risk in Turkish Patients
TURKISH JOURNAL OF HEMATOLOGY, cilt.32, sa.4, ss.311-316, 2015 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 4
- Basım Tarihi: 2015
- Doi Numarası: 10.4274/tjh.2014.0126
- Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.311-316
- Anahtar Kelimeler: 1L-18, Chronic lymphocytic leukemia, Chronic myelogenous leukemia, Single nucleotide polymorphisms, NORTH INDIAN POPULATION, PROINFLAMMATORY CYTOKINE, PROSTATE-CANCER, IL-18, EXPRESSION, CARCINOMA, RECEPTOR, CELLS, ASSOCIATION, SUSCEPTIBILITY
- Ankara Üniversitesi Adresli: Hayır
Özet
Objective: Interleuldn-18 (IL-18) is a cytokine that belongs to the IL-1 superfamily and is secreted by various immune and nonimmune cells. Evidence has shown that 1L-18 has both anticancer and procancer effects. The aim of this study was to evaluate the relationship between IL-18 gene polymorphisms and susceptibility to chronic lymphocytic leukemias (CLL) and chronic myelogenous leukemias (CML) in Turkish patients.