A selective and molecular imaging approach for anticancer drug: Pemetrexed by nanoparticle accelerated molecularly imprinting polymer

ÖZÇELİKAY G., Karadas-Bakirhan N., TAŞKIN TOK T., Ozkan S. A.

Electrochimica Acta, cilt.354, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 354
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.electacta.2020.136665
  • Dergi Adı: Electrochimica Acta
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Anahtar Kelimeler: Molecularly imprinted polymer, Molecular imaging, Anticancer drug, Carbon quantum dots, Voltammetry, MASS-SPECTROMETRY METHOD, ELECTROCHEMICAL SENSOR, ELECTRODE, VALIDATION, SODIUM, DISODIUM, PLASMA, AGENT
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2020 Elsevier LtdA new molecularly imprinting polymer (MIP) based sensor was developed for the selective detection of pemetrexed (PMX) by the electropolymerization of ortho phenylenediammine (o-PD) on carbon quantum dot modified screen printed carbon electrode (CQD/SPCE). The surface characterization was performed with cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The conditions such as casting amount of CQD, incubation time, removal time for successful polymerization were tested. The selectivity of developed sensor also tested with similar compounds with PMX. The results showed that the developed sensor could achieve to detection of PMX from synthetic serum sample with high recovery 99.3%. From the computational perspective of view, PMX was also optimized at B3LYP/6-311 G∗//DFT level using the Gaussian 09 program package. Molecular electrostatic potential surface (MESP) was performed to investigate effects of the electronic and structure properties of PMX.