Akademik Veri Yönetim Sistemi
Turkderm Deri Hastaliklari ve Frengi Arsivi, cilt.38, sa.2, ss.120-123, 2004 (SCI-Expanded)
Background and design: In this study, clinical profile of patients who had undergone allogeneic hematopoietic stem cell transplantation (AHCT) and later developed chronic graft versus host disease (CGVHD) related oral lichenoid lesions are analysed. Materials and methods: Records of 25 patients who received AHCT between years 1996 to 2002 from HLA matched sibling donors at the stem cell transplantation unit were analysed. Patients were followed-up for a mean time of 25.48±17.21 months (range:6-70). Results: Of the 25 patients 13 were female and 12 were men. Mean age was 30.6±8.84 (range:17-46) at the time of AHCT. Oral lichenoid lesions developed after 8.5±5.63 months (range:1-24) folllowing the transplantation. White plaque was the most frequent manifestation and buccal mucosa was the most affected localisation. Approximately half of the patients were asymptomatic while the others had pain, xerostomia or difficulty in swallowing. Three of the patients had only oral lesions without cutaneous involvement of CGVHD; 22 patients had both oral and cutaneous lichenoid CGVHD. Of these 22 patients, 3 (%13.6) patients developed oral lesions 1-3 months before the onset of cutaneous disease. During follow-up, 22 of the 25 patients also had other organ involvements (liver, eye, lung, gastrointestinal system, kidney) of CGVHD. Conclusion: CGVHD related oral lichenoid lesions, which may appear in different clinical forms, are important in the early diagnosis and treatment of CGVHD. Besides, oral lesions are accompanied by widespread CGVHD in a great majority of patients. We suggest that oral mucosa examinations should be periodically performed in all patients including asymptomatic ones who undergo AHCT.