Activities of purine-pyrimidine and free radical metabolising enzymes in human cutaneous carcinomas

Canbolat O., Yilmaz S., Ozgen G., Ercocen A., ELGÜN ÜLKAR S., CAN Z.

CANCER RESEARCH THERAPY & CONTROL, cilt.5, sa.4, ss.301-306, 1998 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 4
  • Basım Tarihi: 1998
  • Dergi Adı: CANCER RESEARCH THERAPY & CONTROL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.301-306
  • Anahtar Kelimeler: cutaneous carcinoma, DNA turnover, antioxidant enzymes, peroxidation, ADENOSINE-DEAMINASE, SUPEROXIDE-DISMUTASE, XANTHINE-OXIDASE, TISSUES, CARCINOGENESIS, DISEASE, BLADDER, CANCER
  • Ankara Üniversitesi Adresli: Evet

Özet

Activities of adenosine deaminase (ADA), cytidine deaminase (CD), xanthine oxidase (XO), hypoxanthine-guanine phosphoribosyl transferase (HGPRT), superoxide dismutase (SOD), catalase (CAT) and thiobarbituric acid reagent substance (TBARS) levels were measured in cancerous skin tissues, cancer free adjacent skin tissues and non-tumoral distant cutaneous tissues obtained from 9 patients with cutaneous carcinomas being basal cell carcinomas and squamous cell carcinomas. Increased ADA, decreased CD and XO activities along with unchanged HGPRT, SOD, CAT activities and TEARS levels were found in cancerous tissues when compared with cancer free adjacent tissue and non-tumoral distant tissues.