Flavin Containing Monooxygenases and Metabolism of Xenobiotics

Basaran R., Can Eke B.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.14, sa.1, ss.90-94, 2017 (ESCI, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 14 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tjps.30592
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.90-94
  • Anahtar Kelimeler: Flavin monooxygenase, microsomal enzymes, phase 1 reactions, GENETIC POLYMORPHISMS, DRUG-METABOLISM, SEX STEROIDS, EXPRESSION, MOUSE, LIVER, LOCALIZATION, RABBIT, RAT, FMO
  • Ankara Üniversitesi Adresli: Evet

Özet

This review summarizes recent information concerning the pharmacological and toxicological significance of the flavin-containing monooxygenases (FMOs). FMOs are a family of microsomal enzymes involving in the oxygenation of certain xenobiotics and drugs containing nucleophilic heteroatoms. The activities of FMOs in drug metabolism and their relationships with diseases are the areas of research requiring further exploration. Future studies on FMOs may provide considerable information about the pathophysiology of diseases and the information related to this enzyme family may be important for drug designs in future.