Prospective randomized comparison of morning versus night daily single subcutaneous administration of granulocyte-macrophage-colony stimulating factor in patients with soft tissue or bone sarcoma

Dincol D., Samur M., Pamir A., Sencan O., Akbulut H., Yalcin B., ...More

CANCER, vol.88, no.9, pp.2033-2036, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 88 Issue: 9
  • Publication Date: 2000
  • Journal Name: CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2033-2036
  • Keywords: neutropenia, granulocyte-macrophage-colony stimulating factor, chronotherapy, chemotherapy, hematopoietic growth factors, MARROW
  • Ankara University Affiliated: Yes

Abstract

BACKGROUND. Hematopoietic growth factors (HGFs) have been used to reduce the neutropenic complications of cytotoxic chemotherapy so that higher doses may be given. The authors have previously shown that endogenous serum granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) levers at night (p.m.) were significantly higher than those in the morning (a.m.).