Prospective randomized comparison of morning versus night daily single subcutaneous administration of granulocyte-macrophage-colony stimulating factor in patients with soft tissue or bone sarcoma

Dincol D., Samur M., Pamir A., Sencan O., Akbulut H., Yalcin B., ...Daha Fazla

CANCER, cilt.88, sa.9, ss.2033-2036, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 88 Sayı: 9
  • Basım Tarihi: 2000
  • Dergi Adı: CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2033-2036
  • Anahtar Kelimeler: neutropenia, granulocyte-macrophage-colony stimulating factor, chronotherapy, chemotherapy, hematopoietic growth factors, MARROW
  • Ankara Üniversitesi Adresli: Evet

Özet

BACKGROUND. Hematopoietic growth factors (HGFs) have been used to reduce the neutropenic complications of cytotoxic chemotherapy so that higher doses may be given. The authors have previously shown that endogenous serum granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) levers at night (p.m.) were significantly higher than those in the morning (a.m.).