Free radical scavenging activity of novel thiazolidine-2,4-dione derivatives

Berczynski P., Kruk I., Piechowska T., Ceylan-Unlusoy M., Bozdag-Duendar O., Aboul-Enein H. Y.

LUMINESCENCE, cilt.28, sa.6, ss.900-904, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1002/bio.2454
  • Dergi Adı: LUMINESCENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.900-904
  • Anahtar Kelimeler: 1, 1-diphenyl-2-picrylhydoxyl radical, chemiluminescence, EPR, hydroxyl radical, spin trapping, superoxide radical, thiazolidine 2, 4-dione derivatives, REACTIVE OXYGEN, SUPEROXIDE, CHEMILUMINESCENCE, CHEMISTRY
  • Ankara Üniversitesi Adresli: Evet

Özet

Free radical activity towards superoxide anion radical (O-2(center dot)), hydroxyl radical (HO center dot) and 2,2-diphenyl-1-picrylhydrazyl (DPPH center dot) of a series of novel thiazolidine-2,4-dione derivatives (TSs) was examined using chemiluminescence, electron paramagnetic resonance (EPR) and EPR spin trapping techniques. 5,5-Dimethyl-1-pyrroline-N-oxide (DMPO) was applied as the spin trap. Superoxide radical was produced in the potassium superoxide/18-crown-6 ether dissolved in dimethyl sulfoxide. Hydroxyl radical was generated in the Fenton reaction (Fe(II) + H2O2. It was found that TSs showed a slight scavenging effect (15-38% reduction at 2.5 mmol/L concentration) of the DPPH radical and a high scavenging effect of (O-2(center dot)) (41-88%). The tested compounds showed inhibition of HO center dot -dependent DMPO-OH spin adduct formation (the amplitude of EPR signal decrease ranged from 20 to 76% at 2.5 mmol/L concentration. Our findings present new group compounds of relatively high reactivity towards free radicals. Copyright (c) 2012 John Wiley & Sons, Ltd.