Excessive naked megakaryocyte nuclei in myelodysplastic syndrome mimicking idiopathic thrombocytopenic purpura: A complicated pre- and post-transplantation course

Olcay L., TUNCER A., OKUR H., ERDEMLİ E., Uysal Z., Çetin M., ...Daha Fazla

Pediatric Hematology and Oncology, cilt.26, sa.6, ss.387-397, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 6
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/08880010902891891
  • Dergi Adı: Pediatric Hematology and Oncology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.387-397
  • Anahtar Kelimeler: Apoptosis, Dysmegakaryopoiesis, Myelodysplastic syndrome, Naked megakaryocyte nuclei, Refractory thrombocytopenia
  • Ankara Üniversitesi Adresli: Evet

Özet

A boy 3 years 7 months old with thrombocytopenia and history of intracranial hemorrhage who underwent bone marrow transplantation is presented. He was refractory to steroids, immunoglobulin G, vincristine, azathioprine, cyclosporine A, interleukin-11, chemotherapy, and splenectomy. Idiopathic thrombocytopenic purpura was excluded by light /electron microscopic and flow cytometric findings; the diagnosis of refractory cytopenia, a subgroup of pediatric myelodysplastic syndrome, was made. Naked megakaryocyte nuclei were 55.38 ± 28.2% vs. 31.67 ± 23.22% of all megakaryocytes in the patient and the control group of 9 patients with idiopathic thrombocytopenic purpura, respectively (p =.016). The posttransplatation course was complicated by delayed platelet engraftment, bronchiolitis obliterans associated with pneumocystis carinii pneumonia, which resolved completely. Copyright © Informa Healthcare USA, Inc.