Pleural mesothelioma in a nine-month-old dog

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Vural S., Ozyildiz Z., Ozsoy S. Y.

IRISH VETERINARY JOURNAL, cilt.60, sa.1, ss.30-33, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1186/2046-0481-60-1-30
  • Dergi Adı: IRISH VETERINARY JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.30-33
  • Anahtar Kelimeler: mesothelionna, pleura, dog, MALIGNANT MESOTHELIOMA, CARCINOEMBRYONIC ANTIGEN, KERATIN PROTEINS, DIFFERENTIAL-DIAGNOSIS, MONOCLONAL-ANTIBODIES, VIMENTIN, IMMUNOPEROXIDASE, ADENOCARCINOMA, ASBESTOS, AID
  • Ankara Üniversitesi Adresli: Evet

Özet

This paper reports on an unusual case of pleural epitheloid mesothelioma in a nine-month-old male, mixed breed dog. The dog was presented in-extremis and, on post mortem examination, multiple, exophytic, frequently pedunculated, yellowish-red, soft to firm masses ranging from 3mm to 6cm in diameter were diffusely distributed over, and attached to, the pericardial and parietal pleural surfaces. Microscopically, these masses consisted of round to partially polygonal-shaped, anaplastic cells with minimal cytoplasm and hyperchromatic nuclei covering papillomatous projections or as part of more densely cellular masses. A supporting fibrovascular stroma and mitotic figures were also evident. Constituent tumour cells were labeled positively with antibodies against both vimentin and cytokeratin. In contrast, the same cells exhibited equivocal labeling with an antibody directed against calretinin antigen and did not label with antibodies against carcinoembryonic antigen (CEA) and milk fat globule-related antigen (MFGRA). Such tumours are rare in dogs, particularly in such a young animal.