Synthesis and antidiabetic activity of some new furochromonyl-2,4-thiazolidinediones

Bozdag-Dundar O., Verspohl E., Waheed A., Ertan R.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.53, sa.12, ss.831-836, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 12
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1055/s-0031-1299837
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.831-836
  • Anahtar Kelimeler: furochromones, furochromonyl-2,4-thiazolidinediones, antidiabetic activity in vitro, synthesis, khellin, HYPOGLYCEMIC ACTIVITY, FLAVONE DERIVATIVES, AGENT CS-045, COMMUNICATION, NIDDM, CELLS, PATHOGENESIS
  • Ankara Üniversitesi Adresli: Evet

Özet

A new series of furochromone-2,4-thiazolidinedione derivatives (Vila-h) was prepared by Knoevenagel reaction of substituted-2,4-thiazolidinediones (VIa-h) with Khellin-2-carboxaldehyde (IV). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds VIId and VIIf (at lower concentration; 1 mug/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose. Both these compounds (VIId and VIIf) and VIIg increased glucose uptake in NIH-3T3 cells. Thus these 3 compounds should be tested for antidiabetic effects in vivo.