Pegylation: preparation and application of PEG conjugates Pegi̇lasyon: PEG konjugatlarinin hazirlanmasi ve uygulamalari

SEZGİN BAYINDIR Z., YÜKSEL N.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.36, sa.4, ss.249-266, 2007 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 36 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1501/eczfak_0000000540
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.249-266
  • Anahtar Kelimeler: Pegylation, Pegylation chemistry, Peptide-protein, Polyethylene glycol
  • Ankara Üniversitesi Adresli: Evet

Özet

Pegylation is defined as the modification of especially protein-peptide molecules by the linking of one or more polyethylene glycol (PEG) chains. PEG is a nontoxic, non-immunogenic, non-antigenic, highly water soluble and FDA approved polymer. The PEG-drug conjugates have several advantages: a prolonged residence in body, a decreased degradation by metabolic enzymes and a reduction or elimination of protein immunogenicity. Today the potential of peptides and proteins usage as therapeutic agents is enhanced via pegylation. In this publication definition and benefits of pegylation, PEG derivates used for modification, applications of pegylation in pharmaceutical area and the limiting factors of PEG usage is reviewed.