Variations in glutathione-S-transferase genes influence risk of chronic myeloid leukemia

Oezten N., SUNGUROĞLU A., Bosland M. C.

HEMATOLOGICAL ONCOLOGY, cilt.30, sa.3, ss.150-155, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1002/hon.1018
  • Dergi Adı: HEMATOLOGICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.150-155
  • Anahtar Kelimeler: polymorphism, CML, GSTM1, GSTT1, NULL GENOTYPE FREQUENCY, BLADDER-CANCER, T1 GENOTYPES, POLYMORPHISMS, GSTT1, GSTM1, THETA, M1, SUSCEPTIBILITY, BENZENE
  • Ankara Üniversitesi Adresli: Evet

Özet

Glutathione S-transferases (GSTs) are phase II enzymes that detoxify hazardous xenobiotics including carcinogens. Inter-individual variations in GSTM1 and GSTT1 loci have been associated with several types of cancer, including leukemias. In this study, we investigated the possible association between GSTM1 and GSTT1 polymorphisms and susceptibility to chronic myeloid leukemia (CML) in a Turkish population. In a case-control study, 106 CML patients and 190 healthy controls were evaluated for GSTM1 and GSTT1 polymorphisms. GSTM1 null (GSTM1-) genotype frequencies in CML cases and controls were 45.3% and 42.6%, respectively. GSTT1 null (GSTT1-) genotype frequencies were 44.3% and 18.4%, respectively. The frequency of the GSTT1- genotype among CML patients was significantly higher than in controls [odds ratio (OR) 3.53, 95% confidence interval (CI) 2.08-6.00; P?