Antimicrobial activity of some thiadiazolyl- and triazolylbenzimidazoles

KUŞ C., Ayhan-Kilcigil G., ALTANLAR N.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.33, sa.1, ss.1-6, 2004 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 1
  • Basım Tarihi: 2004
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-6
  • Anahtar Kelimeler: Antimicrobial activity, Thiadiazolylbenzimidazoles, Thiosemicarbazides, Triazolylbenzimidazoles
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, thirty nine benzimidazole derivatives namely 1-[(substituted thiocarbamoylhydrazine carbonyl)methyl]-2-phenyl-1H-benzimidazoles 1a-13a, N-[(2-phenylbenzimidazol-1-yl methyl)-[1,3,4]-thiadiazole-2-yl]-substituted phenyl amines 1b-13b, and 5-(2-phenyl benzimidazol-1-yl-methyl-4-substituted phenyl-4H-1,2,4-triazole-3-thiones 1c-13c were screened for their antimicrobial activities. Minimum Inhibitory Concentration (MIC) values of the compounds were determined by the tube dilution method using Staphylococcus aureus and Bacillus subtilis as Gram positive. Escherichia coli as Gram negative bacteria and Candida albicans. Candida krusei and Candida parapsilosis as yeast-like fungi. All of the compounds were inactive against S. aureus, C. krusei and C. parapsilosis Compounds 5b, 9a and 13a (12.5 μg/ml) showed good inhibitory activity against C. albicans.