Intron F G79a polymorphism of the protein Z gene in cancer patients with and without thrombosis

Eroglu A., Ozturk A., Çam R., Akar N.

Journal of Thrombosis and Thrombolysis, vol.27, no.2, pp.204-206, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1007/s11239-008-0199-9
  • Journal Name: Journal of Thrombosis and Thrombolysis
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.204-206
  • Keywords: Cancer, Polymorphism, Protein Z gene, Thrombosis
  • Ankara University Affiliated: Yes

Abstract

Background and Purpose: Venous thromboembolism (VTE) is well-recognized complication of cancer; however its pathogenesis is not entirely established. Protein Z (PZ) is a member of the coagulation cascade. We aimed to investigate whether intron F G79A polymorphism of PZ gene is associated with risk of VTE in cancer patients. Materials and Methods: The study consisted of 55 cancer patients who developed thrombosis (group 1) and 115 cancer patients without VTE (group 2). Intron F G79A of PZ gene, factor V Leiden (FVL) and prothrombin (PT) G20210A polymorphisms were determined by the method of polymerase chain reaction-based DNA analysis. Results: The prevalence of FVL was significantly greater in group 1 compared with group 2 (27.3% vs. 3.5%, P < 0.0001). No differences were seen in genotype and allele frequencies of PZ gene between two groups (P > 0.05). When the analysis was also made after excluding FVL positive patients, the same insignificant result was found. Conclusion: Intron F G79A polymorphism of PZ gene does not contribute to meaningful diagnostic investigation of thrombophilia in cancer patients. © Springer Science+Business Media, LLC 2008.