The Use of Fundus Autofluorescence in Dry Age-Related Macular Degeneration

KEŞKEK N. Ş., ŞERMET F.

TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY, cilt.51, sa.3, ss.169-176, 2021 (ESCI) identifier identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 51 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.4274/tjo.galenos.2020.49107
  • Dergi Adı: TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.169-176
  • Anahtar Kelimeler: Age-related macular degeneration, fundus autofluorescence, geographic atrophy, lipofuscin, retina, RETINAL-PIGMENT EPITHELIUM, GEOGRAPHIC ATROPHY, FELLOW EYE, RETICULAR PSEUDODRUSEN, IN-VIVO, LIPOFUSCIN, PATTERNS, PROGRESSION, TOPOGRAPHY, LIFETIMES
  • Ankara Üniversitesi Adresli: Evet

Özet

Fundus autofluorescence (FAF) has been a well-known imaging method for quite some time. However, with developing technologies and novel imaging devices, FAF is being used more often to diagnose and monitor retinal diseases. The density of lipofuscin (LF) and other fluorophores in the retina have a determining role in FAF images. In dry age-related macular degeneration (AMD), hyperautofluorescence is seen in cases of increasing LF in the retina pigment epithelium, whereas hypoautofluorescence is detected in decreasing LF resulting from geographic atrophy. In recent years, studies have shown that FAF images provide prognostic information in patients with AMD. This review aims to highlight the importance of FAF imaging in dry AMD.