Effect of Catalytically Active Zinc Oxide−Carbon Nanotube Composite on Sensitive Assay of Desloratadine Metabolite

Ozturk K., BAKIRHAN N. K., Ozkan S. A., USLU B.

Electroanalysis, cilt.32, sa.1, ss.50-58, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/elan.201900193
  • Dergi Adı: Electroanalysis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.50-58
  • Anahtar Kelimeler: Electrochemistry, Nanosensor, Pharmaceutical Analysis, Desloratadine, STRIPPING VOLTAMMETRIC DETERMINATION, ELECTROCHEMICAL DETERMINATION, NANOPARTICLES, SENSOR, ACID
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimDesloratadine is one of the most effective second-generation antihistamines and the electrochemical behavior of the active agent of desloratadine was investigated with a new nanosensor designed with the addition of zinc oxide and multiwalled carbon nanotube (ZnO : MWCNT) mixture on glassy carbon (GCE). By investigating and using cyclic, differential pulse and square wave voltammetry techniques with ZnO : MWCNT/GCE, it is planned to obtain information about quantification and mechanism of desloratadine. The efficiency of experimental parameters such as pH, scan rate, accumulation potential and time on the anodic response of desloratadine were studied. Differential pulse voltammetry was selected as assay method and under developed method and optimized conditions, the current showed linear dependence with concentration in the range between 2×10−8 and 8×10−6 M in pH 5.5 acetate buffer. The achieved limits of detection (LOD) and quantification (LOQ) are 0.769 nM and 2.56 nM respectively. Applicability of the methods was demonstrated by their implementation in pharmaceutical dosage forms of desloratadine and the accuracy, precision, selectivity, sensitivity, intra-day and day-to-day reproducibility of the methods were clearly explored. Finally, this sensor was successfully applied on real sample as a selective, simple, reproducible, repeatable an electrochemical sensor.