Cytotoxic and Apoptotic Effects of Novel Pyrrolo[2,3-d]Pyrimidine Derivatives Containing Urea Moieties on Cancer Cell Lines

KILIÇ KURT Z., BAKAR ATEŞ F., Karakas B., Kutuk O.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.18, sa.9, ss.1303-1312, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 9
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1871520618666180605082026
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1303-1312
  • Anahtar Kelimeler: Pyrrolo[2, 3-d]pyrimidines, anticancer activity, apoptosis, cell cycle, western blot analysis, urea moieties, TYROSINE KINASE INHIBITOR, BIOLOGICAL EVALUATION, PHASE-I, DESIGN, PYRROLOPYRIMIDINE, ANTITUMOR, POTENT, NUCLEOSIDE, DISCOVERY
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Pyrrolo[2,3-d]pyrimidines have been recently reported to have anticancer activities through inhibition of different targets such as, Epidermal Growth Factor Receptor (EGFR) tyrosine kinase, Janus Kinase (JAK), mitotic checkpoint protein kinase (Mps1), carbonic anhydrase, MDM-2. On the other hand, aryl urea moieties which are found in some tyrosine kinase inhibitors such as Sorafenib and Linifanib have aroused recent attention as responsible for anticancer activities. The aims of this paper are to synthesize pyrrolo[2,3-d]pyrimidine derivatives containing urea moiety and evaluate their anti-cancer activity against human lung cancer cell line (A549), prostate cancer cell line (PC3), human colon cancer cell line (SW480) and human breast cancer cell line (MCF-7).