Comutagenesis-I: The in vitro metabolism of 2-amino-3-methylpydidine

ALTUNTAŞ T., Manson D., Zhao K., Gorrod J.

ANTICANCER RESEARCH, cilt.17, sa.5A, ss.3485-3491, 1997 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 5A
  • Basım Tarihi: 1997
  • Dergi Adı: ANTICANCER RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3485-3491
  • Anahtar Kelimeler: comutagenesis, metabolism, 2-amino-3-methylpyridine, oxidative metabolites, synthesis of potential metabolites, NORHARMAN
  • Ankara Üniversitesi Adresli: Hayır

Özet

The metabolism of the comutagen 2-amino-3-methylpyridine has been studied in vitro using rat and rabbit hepatic preparations. 2-Amino-3-methylpyridine-N-oxide, 2-amino-3-hydroxymethylpyrdine and 2-amino-5-hydroxy-3-methylpyridine were formed by both rat and rabbit hepatic preparations. No evidence was obtained for the formation of the corresponding 2-hydroxylamine, 2-nitroso, 2-nitro-3-methylpyridine or their condensation products i.e. ate, azoxy or hydrate. The results are discussed in relation to the possible mechanism of action of the substrate.