Synthesis and antimicrobial activities of some new flavonyl pro-drug esters of ampicillin

Unlusoy M., Altanlar N., Ertan R.

TURKISH JOURNAL OF CHEMISTRY, cilt.29, sa.2, ss.187-191, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 2
  • Basım Tarihi: 2005
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.187-191
  • Anahtar Kelimeler: flavone derivatives, ampicillin, pro-drug ester, antimicrobial activities, INVITRO, ACID
  • Ankara Üniversitesi Adresli: Evet

Özet

A new series of flavonyl pro-drug esters of ampicillin (Va-b) was prepared by condensing the appropriate bromomethyl flavone with ampicillin trihydrate potassium salt. Flavone. derivatives and ampicillin both have good antibacterial activity. The synthesized compounds were tested for their antifungal and antibacterial activities in vitro. Both of the compounds were active against Candida krusei and Staphylococcus aureus.