Akademik Veri Yönetim Sistemi
34th European Congress of Pathology, Basel, İsviçre, 3 - 07 Eylül 2022, ss.1
Road-mapping for gastric intestinal metaplasia
E.K. Çagdas*, İ. Adanır, C. Ersöz, Ş. Ersöz, B. Savaş, A. Ensari
*Ankara University School of Med., Turkey
Background & objectives: Uneven distribution of gastric intestinal metaplasia (GIM) may require mapping biopsies rather than random biopsies which may fail to reflect the extent of the lesions. We, hereby, evaluated the value of mapping in determining the extent and severity of IM.
Methods: Random biopsies (RB) obtained according to updated Sydney protocol and mapping biopsies (MB) taken from 6 different sites of corpus and antrum during surveillance were evaluated for the severity and extent of histologic parameters of gastritis, mainly focusing on GIM with atrophy in a cohort of 202 patients. Statistical analysis was performed using Wilcoxon test on SPSS version 22.
Results: Mean age of 202 patients (104 females, 86 males) was 61.78±11,5 years. Average time interval between RB and MB was 18 months. There were 98 cases with isolated antral IM and 75 cases with isolated corpus IM in RB while MB revealed IM in the corpus in 13 of 98 cases (13.26%) and antral IM in 23 of 75 (30.66%) cases. IM at both sites was observed in 17 (8.9%) RB and 31 (16.4%) MB which yielded a significant increase by an increment of 1.84 (p<0.05). Severity of antral IM significantly increased in MB in 28% of cases (p<0.05) while no such difference was found for corpus IM.
Conclusion: The results of the present study suggest that mapping with multiple biopsies improves the detection rate of IM both in the corpus and antrum, providing information for the extent and severity of the lesions. This approach also seems to be useful in cases with isolated antral IM in monitoring severity of IM as already demonstrated by MB taken from the antrum in our study. However, large prospective, randomized, multicentre studies comparing different follow-up strategies are necessary for a better roadmap.
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