Akademik Veri Yönetim Sistemi
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.50, sa.1, ss.175-190, 2026 (Scopus, TRDizin)
Objective: In this review, it is aimed to classify and introduce glucose-sensitive hydrogels prepared for the treatment of insulin-dependent diabetes patients. The insulin release mechanisms of these hydrogels prepared from various glucose-sensitive materials and their efficacy in diabetes treatment are focused on. Result and Discussion: Insulin dependent diabetes patients should be given sufficient amount of insulin when needed. Otherwise, various complications occur in the patient whose blood glucose levels cannot be kept within the normal range. Glucose-sensitive materials, glucose oxidase, concanavalin A, or phenylboronic acid can be integrated into hydrogels to develop therapeutic systems that can mimic the blood glucose concentration-dependent insulin release profiles of the pancreas. Hydrogels containing glucose-sensitive material can respond to the changing blood glucose levels of the diabetic patient. Glucose-sensitive macro, micro and nano-sized hydrogels and composite hydrogels that can be administered to patients in different ways for diabetes treatment have been prepared. These hydrogels, which can regulate insulin release with an on-off mechanism, have the potential to manage blood glucose in patients in the treatment of diabetes.