Macular structural changes and factors affecting final visual acuity in patients with Behcet uveitis

YALÇINDAĞ F. N., Temel E., Sekkeli M. Z., KAR İ.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, cilt.259, sa.3, ss.715-721, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 259 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s00417-020-04958-4
  • Dergi Adı: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.715-721
  • Anahtar Kelimeler: Behcet uveitis, Optical coherence tomography, Epiretinal membrane, Uveitic macular edema, Ellipsoid zone, OPTICAL COHERENCE TOMOGRAPHY, DISEASE, INNER, REMISSION, BARRIER
  • Ankara Üniversitesi Adresli: Evet

Özet

Purpose To evaluate macular structural changes during the active and remission periods in patients with Behcet uveitis and to further assess the factors affecting final visual acuity. Methods Clinical records and spectral domain-optical coherence tomography (SD-OCT) findings of patients with Behcet uveitis were retrospectively reviewed. Results Sixty-nine eyes of 35 patients were included in the study. SD-OCT findings in the active uveitis period included epiretinal membrane (ERM) in 26 (37.1%) eyes, ellipsoid zone (EZ) damage in 11 (15.7%), external limiting membrane (ELM) damage in 10 (14.3%), macular atrophy in 6 (8.6%), disruption of retinal pigment epithelium (RPE) in 11 (15.7%), a macular scar in 1 (1.4%), and loss of normal foveal contour appearance in 15 (21.4%). There was macular edema in 23 eyes (32.9%) in the active uveitis period (11 (15.7%) cystoid macular edema, 10 (14.3%) diffuse macular edema, and 7 (10.0%) serous retinal detachment). In the remission period, SD-OCT findings included ERM in 37 (52.9%) eyes, EZ damage in 14 (20%), ELM damage in 14 (20%), macular atrophy in 7 (10%), disruption of RPE in 14 (20.0%), macular scar in 1 (1.4%), and loss of normal foveal contour appearance in 17 (24.3%). The mean central macular thickness in the remission period was significantly lower than in the active uveitis period (p< 0.001). The presence of EZ damage and loss of normal foveal contour appearance in active uveitis period were the independent factors associated with final visual acuity (logMAR) (beta= 0.736,p= 0.003;beta= 0.682,p= 0.002, respectively). Conclusion Ellipsoid zone damage and loss of normal foveal contour appearance are important factors affecting visual acuity in Behcet uveitis.