Effects of Caproic and Caprylic Acids on Microbial Growth and Cytotoxicity

Hismiogullari S. E., Elyurek E., Hismiogullari A. A., Sahin F., Basalan M., Yenice S.

JOURNAL OF ANIMAL AND VETERINARY ADVANCES, cilt.7, sa.6, ss.731-735, 2008 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 6
  • Basım Tarihi: 2008
  • Dergi Adı: JOURNAL OF ANIMAL AND VETERINARY ADVANCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.731-735
  • Anahtar Kelimeler: Hexanoic acid, octanoic acid, S. aureus, E. coli, cytotoxicity, POLYUNSATURATED FATTY-ACIDS, MEDIUM-CHAIN MONOGLYCERIDES, STAPHYLOCOCCUS-AUREUS, HELICOBACTER-PYLORI, IN-VITRO, ANTIMICROBIAL ACTIVITY, METHICILLIN-RESISTANT, LAURIC ACID, COMBINATION
  • Ankara Üniversitesi Adresli: Evet

Özet

In order to assess the potential use of fatty acids and their derivatives as alternatives to the regionally banned antibiotics, the bacteriocidal and cytotoxic effects of caproic (hexanoic) and caprylic (octanoic) acids were investigated. Fatty acids at various concentrations were added to media containing Staphylococcus aureus, Escherichia coli and murine fibroblast cells. At 0.5% (w/v) concentration of hexanoic acid, both S. aureus and E. coli growth occurred, however, octanoic acid was effective on inhibition of growth of both bacteria above 1% level. At the same time octanoic acid above 0.5%, hexanoic acid above 0.25% levels inhibited mammalian cell growth. Both acids decreased the medium pH linearly with increasing concentration. Further investigation is needed to prove that they may be usable for in vivo applications.