Synthesis and Antistaphylococcal Activity of N-Substituted-1H-benzimidazole-sulphonamides

PÜSKÜLLÜ M. O., Yildiz S., GÖKER A. H.

ARCHIV DER PHARMAZIE, cilt.343, sa.1, ss.31-39, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 343 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1002/ardp.200900199
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.31-39
  • Anahtar Kelimeler: Anti-staphylococcal activity, 1H-Benzimidazolesulphonamide, Methicillin-resistant Staphylococcus aureus, Tautomerism, ANTIMICROBIAL ACTIVITY, INHIBITORS
  • Ankara Üniversitesi Adresli: Evet

Özet

A series of N-substituted-1H-benzimidazole-5(6)-sulfonamides and 3-(5,6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzensulfonamides were synthesized and evaluated for antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Certain compounds inhibit bacterial growth with low MIC (mu g/mL) values. The most active compounds 30, 31, and 32 have the lowest MIC values with 0.39 to 0.19 mu g/mL. Among the compounds having sulfonamido moities, 16, 23, and 24 exhibited the strongest antibacterial activity with 1.56 mu g/mL MIC values.