Antioxidant Properties of Melatonin and its Potential Action in Diseases

Karaaslan C., SÜZEN S.

CURRENT TOPICS IN MEDICINAL CHEMISTRY, cilt.15, sa.9, ss.894-903, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 15 Sayı: 9
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2174/1568026615666150220120946
  • Dergi Adı: CURRENT TOPICS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.894-903
  • Anahtar Kelimeler: Antioxidant, Cancer, Diabetes, Immune system, Inflammatory diseases, Melatonin, Neurodegenerative disorders, Radiation, OXIDATIVE STRESS, INSULIN-RESISTANCE, SECRETION PATTERN, REACTIVE OXYGEN, DAMAGE, RADIATION, CANCER, MODEL, SLEEP, METABOLITES
  • Ankara Üniversitesi Adresli: Evet

Özet

In recent years, relationship between free radicals and oxidative stress with aging, cancer, atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases became increasingly clear. Confirming the role of oxidants in numerous pathological conditions such as cancer, the antioxidants developed as therapeutics have been proven ineffective. It is well established that melatonin (MLT) and its metabolites are able to function as endogenous free-radical scavengers and broad-spectrum antioxidants. Numerous studies also proved the role of MLT and its derivatives in many physiological processes and therapeutic functions, such as the regulation of circadian rhythm and immune functions. The aim of this review is to arouse attention to MLT as a potentially valuable agent in the prevention and/or treatment of some diseases.