Electrochemical Investigation of Ruxolitinib: Sensitive Voltammetric Assay in Drug Product and Human Serum by Using Different Solid Electrodes

Bilge S., KARADURMUŞ L., Atici E. B., SINAĞ A., ÖZKAN S. A.

ELECTROANALYSIS, cilt.34, sa.8, ss.1318-1328, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 8
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1002/elan.202100625
  • Dergi Adı: ELECTROANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1318-1328
  • Anahtar Kelimeler: Ruxolitinib, voltammetry, glassy carbon electrode, boron-doped diamond electrode, method validation, mechanism, CARBON, NANOPARTICLES
  • Ankara Üniversitesi Adresli: Evet

Özet

Ruxolitinib (RUX), a compound of the pyrrolopyrimidines class with activity as a tyrosine kinase inhibitory drug, is used to treat myelofibrosis. This study is reported for the detailed electrochemical behavior of RUX. The effects of supporting electrolyte, pH, and scanning rate on the peak potentials and currents of RUX were investigated by BDDE and GCE using different voltammetric techniques. Under optimum experimental conditions, calibration curves for RUX were obtained as 4 mu M-80 mu M and 1 mu M-80 mu M with a limit of detection (LOD) of 0.517 mu M and 0.192 mu M by the GCE and BDDE, respectively using DPV.