Proinflammatory biomarkers' level and functional genetic polymorphisms in periprosthetic joint infection

ERDEMLİ B. A., ÖZBEK E. A., BAŞARIR K., KARAHAN Z. C., ÖCAL D., Biriken D.

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, cilt.52, sa.2, ss.143-147, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.aott.2017.11.002
  • Dergi Adı: ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.143-147
  • Anahtar Kelimeler: Periprosthetic joint infection, Genetic polymorphism, Proinflammatory biomarkers, C-REACTIVE PROTEIN, VENOUS THROMBOEMBOLISM, ALPHA-DEFENSIN, DIAGNOSIS, ASSOCIATION, RISK, DISEASE, IL-6
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: The aims of this study were 1) to identify the level of inflammatory biomarkers interleukin (IL)-1 alpha, IL-1 beta, IL-6, IL-8, IL-17, C-reactive protein (CRP), granulocyte colony-stimulating factor (GCSF), ferritin, and tumor necrosis factor (TNF)-alpha in serum and synovial fluid samples of patients who underwent revision arthroplasty surgery; 2) to establish the relationship between serum and synovial fluid levels; 3) to determine if any of the 11 genetic polymorphisms of TNF alpha, IL-1, IL-6, IL-8, IL-17, and GCSF on the encoding genes was associated with periprosthetic joint infection (PJI).