Caprine arthritis encephalitis virus-induced apoptosis associated with brain lesions in naturally infected kids

Toplu N., Oğuzoğlu T. Ç.

JOURNAL OF COMPARATIVE PATHOLOGY, cilt.206, sa.0, ss.36-43, 2023 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 206 Sayı: 0
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.jcpa.2023.08.008
  • Dergi Adı: JOURNAL OF COMPARATIVE PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.36-43
  • Ankara Üniversitesi Adresli: Evet

Özet

Acute demyelinating leucoencephalomyelitis was the most conspicuous microscopic change in the brain and spinal cord of kids infected with caprine arthritis encephalitis virus (CAEV). TUNEL positivity and labelling of anti-bax and anti-caspases-3, -8 and -9 were found in a distinct population of glial cells, mainly at the edges of the demyelinated plaques and perivascular areas and, to a lesser extent, in neurons. Double labelling revealed that most of these apoptotic cells in the demyelinated plaques were astrocytes and a few were oligodendroglia. In contrast, expression of bcl-2, an anti-apoptotic protein, was found mainly in neurons of the brainstem and cerebellum and motor neurons of the spinal cord, but was restricted in glial cells. These results suggest that apoptosis plays an important role in the pathogenesis of CAE demyelinating encephalitis.