Development and in-vitro evaluation of chitosan chloride decorated PLGA based polymeric nanoparticles of nimesulide

ŞENGEL TÜRK C. T., Bayram B.

JOURNAL OF RESEARCH IN PHARMACY, cilt.25, sa.4, ss.379-387, 2021 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.29228/jrp.28
  • Dergi Adı: JOURNAL OF RESEARCH IN PHARMACY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.379-387
  • Anahtar Kelimeler: Nimesulide, cancer, chitosan chloride, PLGA based polymeric nanoparticles, surface modification, SURFACE MODIFICATION, ANTICANCER ACTIVITY, POLYVINYL-ALCOHOL, FORMULATION, DELIVERY, RELEASE, DESIGN
  • Ankara Üniversitesi Adresli: Evet

Özet

The aim of this study is to develop PLGA based nanoparticle drug delivery systems loaded with nimesulide which is a non-steroidal anti-inflammatory (NSAI) agent and a selective COX-2 inhibitor that proved its antineoplastic and antitumor activity on cancer carsinogenesis and chemotherapy via epidemiological, pathological, clinical and biological studies in the last years, and modify their surface properties using chitosan chloride. For this purpose, Nimesulide loaded PLGA nanoparticles modified with chitosan chloride were developed with solvent evaporation-diffusion-salting out method. Nanoparticle formulations were evaluated for production yield, process efficacy, particle size and polydispersity index (PDI), surface charge, morphologic properties, redispersibility index, residual PVA amount and in vitro dissolution rate profiles. The results obtained showed that surface modification with chitosan chloride was significantly effective statistically on the final properties of the nanoparticles. With this study, it was shown that PVA and chitosan chloride combined can play a key role in developing cationic and positively charged nanoparticles.