Radiation therapy, cisplatin and hyperthermia in combination in management of patients with carcinomas of the head and neck with N2 or N3 metastatic cervical lymph nodes

Serin M., Erkal H., Cakmak A.

RADIOTHERAPY AND ONCOLOGY, vol.50, no.1, pp.103-106, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 1
  • Publication Date: 1999
  • Doi Number: 10.1016/s0167-8140(98)00098-x
  • Journal Name: RADIOTHERAPY AND ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.103-106
  • Keywords: radiation therapy, cisplatin, hyperthermia, head and neck neoplasms, LOCALLY ADVANCED HEAD, PHASE-I-II, RADIOTHERAPY, CIS-DIAMMINEDICHLOROPLATINUM(II), TEMPERATURE, CANCER, TRIAL
  • Ankara University Affiliated: No

Abstract

Fifty-three patients with carcinomas of the head and neck with N2 or N3 metastatic cervical lymph nodes were treated with radiation therapy (median, 70 Gy), cisplatin (median, 6 weekly courses) and hyperthermia (median, 6 twice weekly sessions). Local complete response was achieved in 82% and nodal complete response in 85% of patients. Overall survival was 51% and disease-free survival was 54% at 2 years. Toxicity was acceptable. Radiation therapy, cisplatin and hyperthermia in combination prove to be effective and safe in management of these patients. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.