Studies in vivo of omega-gliadins in gluten sensitivity (coeliac sprue disease)

ENSARİ A., Marsh M., Moriarty K., Moore C., Fido R., Tatham A.

CLINICAL SCIENCE, cilt.95, sa.4, ss.419-424, 1998 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 95 Sayı: 4
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1042/cs19980129
  • Dergi Adı: CLINICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.419-424
  • Anahtar Kelimeler: coeliac, gliadin, in vivo challenge, mucosa, CD3/gamma delta lymphocyte, SMALL-INTESTINAL-MUCOSA, POLYACRYLAMIDE-GEL-ELECTROPHORESIS, S-POOR PROLAMINS, CELIAC-DISEASE, MORPHOMETRIC ANALYSIS, LYMPHOID-TISSUE, MOLECULAR CHARACTERIZATION, ALPHA-GLIADIN, REPEAT MOTIF, CHALLENGE
  • Ankara Üniversitesi Adresli: Evet

Özet

1. Highly purified omega-gliadins from wheat were used to challenge gluten-sensitized individuals. Characteristic responses by mucosal CD3(+) and gamma delta(+) lymphocytes were demonstrated. Each lymphocyte subset showed an increase within 8-12h post-challenge, indicating a specific response by the rectal mucosa to this gliadin species.