Research Information System
Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling, York, United Kingdom, 16 - 19 July 2000, pp.7, (Full Text)
The use of cellulose derivatives as implantation matrices in tissue engineering applications was discussed. A study was done to examine the in vitro and in vivo degradation of macroporous ethyl cellulose (EC) and acetyl cellulose (AC) sponges. The fabricated EC and AC sponges had macropores of ca. 250-400 μm size and the initial concentrations were found to affect both the in vitro and in vivo degradation rates of the polymers. The formed granulation tissue was within the acceptable levels both for the EC and AC sponges. The results show that degradation of the EC and AC sponges could be manipulated by changing polymer concentration. It was found that these macroporous scaffolds could hold a high number of cells, with acceptable tissue reaction.