Evaluation of macroporous ethyl- and acetyl-cellulose sponges for tissue engineering applications

Elçin A. E., Durkut S., Elçin Y. M.

Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling, York, Birleşik Krallık, 16 - 19 Temmuz 2000, ss.7 identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Basıldığı Şehir: York
  • Basıldığı Ülke: Birleşik Krallık
  • Sayfa Sayıları: ss.7
  • Ankara Üniversitesi Adresli: Evet

Özet

The use of cellulose derivatives as implantation matrices in tissue engineering applications was discussed. A study was done to examine the in vitro and in vivo degradation of macroporous ethyl cellulose (EC) and acetyl cellulose (AC) sponges. The fabricated EC and AC sponges had macropores of ca. 250-400 μm size and the initial concentrations were found to affect both the in vitro and in vivo degradation rates of the polymers. The formed granulation tissue was within the acceptable levels both for the EC and AC sponges. The results show that degradation of the EC and AC sponges could be manipulated by changing polymer concentration. It was found that these macroporous scaffolds could hold a high number of cells, with acceptable tissue reaction.