Does Decorin Protect Neuronal Tissue via Its Antioxidant and Antiinflammatory Activity from Traumatic Brain Injury? An Experimental Study

Ozay R., Turkoglu E., Gurer B., Dolgun H., EVİRGEN O., ERGÜDER B. İ., ...Daha Fazla

WORLD NEUROSURGERY, cilt.97, ss.407-415, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 97
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.wneu.2016.09.115
  • Dergi Adı: WORLD NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.407-415
  • Anahtar Kelimeler: Antioxidants, Apoptosis, Decorin, Methylprednisolone, Neuroprotection, Traumatic brain injury, GROWTH-FACTOR-BETA, SPINAL-CORD, OXIDATIVE STRESS, LIPID-PEROXIDATION, TGF-BETA, BLOOD, EXPRESSION, SYSTEM, DAMAGE, METHYLPREDNISOLONE
  • Ankara Üniversitesi Adresli: Evet

Özet

BACKGROUND: The development of secondary brain injury via oxidative stress after traumatic brain injury (TBI) is well known. Decorin (DC) inactivates transforming growth factor beta 1, complement system, and tumor necrosis factor alpha, which are related to oxidative stress and apoptosis. Consequently, the aim of the present study was to evaluate the role of DC on TBI.