The consolidation and compressibility properties of some novel directly compressible filler-binders

Gonul N., HASÇİÇEK C., Baykara T.

Acta Poloniae Pharmaceutica - Drug Research, vol.57, no.4, pp.311-317, 2000 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 4
  • Publication Date: 2000
  • Journal Name: Acta Poloniae Pharmaceutica - Drug Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.311-317
  • Keywords: Compressibility, Consolidation, Dilution potential, Directly compressible filler-binders
  • Ankara University Affiliated: Yes

Abstract

The aim of this study was to investigate the consolidation and compressibility properties and also the dilution potentials of some novel directly compressible filler-binders. For this purpose, Ludipress® and Cellastose® 80 (one-body compounds), Tablettose® 70 and Tablettose® 80 (α-mono agglomerated lactose) were selected. They were diluted at predetermined percentages with Spherolac® 100 which is a coarse sieved hydrous crystalline lactose. The consolidation and compressibility properties of the prepared powder mixtures were determined. The experimental data were evaluated by using a computer programme (Basic 80).