Akademik Veri Yönetim Sistemi
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.37, sa.2, ss.145-170, 2008 (Scopus)
In their evaluation period, modern transdermal therapeutic systems have been evaluated for the delivery of active agents which can not be given especially by oral route or having loss on this route. The major advantage of these systems are to obtain long term effect and to finish the effect or side effects, when it is necessary. One of the major disadvantage of transdermal systems is that many of the active agents can not be given by transdermal route related with their physicochemical properties. This problem has been trying to be solved by using chemical, physical or mechanical penetration enhancement mechanisms. Especially, physical and mechanical methods are on the agenda of the late years. However, these methods have the disadvantages of high production costs and the controversial safety on application areas. Thus, it can be seen that still there is not so many commercial transdermal devices on the market. In this rewiev, transdermal products and devices which are commercial in 2009 or still evaluated clinically and using electrical (iontophoresis, electrophoresis, sonophoresis), physical (thermal ablation, microneedles) or mechanical (pressure wave) penetration enhancement mechanisms were discussed.