Ocular findings of pediatric dry eye related to graft-versus-host disease

BİNGÖL KIZILTUNÇ P., Buyuktepe T. C., YALÇINDAĞ F. N., ERTEM M., İNCE E., Ileri T., ...Daha Fazla

Turkish Journal of Ophthalmology, cilt.51, sa.3, ss.134-138, 2021 (Scopus) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.4274/tjo.galenos.2020.88137
  • Dergi Adı: Turkish Journal of Ophthalmology
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.134-138
  • Anahtar Kelimeler: Cyclosporine-A, dry eye, graft-versus-host disease, pediatric, Schirmer test, STEM-CELL TRANSPLANTATION, BONE-MARROW-TRANSPLANTATION, OPHTHALMIC EMULSION, CYCLOSPORINE-A, RISK-FACTORS, COMPLICATIONS, DIAGNOSIS, EFFICACY, MODERATE, SAFETY
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2021 by Turkish Ophthalmological Association Turkish Journal of Ophthalmology, published by Galenos Publishing House.Objectives: To evaluate the frequency and findings of dry eye associated with ocular graft-versus-host disease (GVHD) in pediatric hematopoietic stem cell transplantation (HSCT) patients. Materials and Methods: Retrospectively the records of pediatric patients with ocular GVHD were evaluated and ophthalmologic examination findings as well as Schirmer test results, tear film break-up time, and corneal staining grades were recorded. In severe dry eye patients topical cyclosporine-A was prescribed and the results were evaluated. Results: GVHD was detected in 51 (23.4%) of 218 HSCT patients, 4 of whom died during follow-up. Thirty (63.8%) of the remaining 47 patients had chronic ocular GVHD and 4 patients with severe dry eye were treated with topical cyclosporine-A with a median follow-up of 12.1 months. Severe dry eye symptoms and findings significantly improved in 2 patients. However, 1 patient had to stop treatment due to side effects. Conclusion: In children, chronic ocular GVHD is a common finding of GVHD after HSCT. Therefore, these patients should be examined periodically for dry eye.