The effect of intravenous erythromycin on solid meal gastric emptying in patients with chronic symptomatic post-vagotomy-antrectomy gastroparesis


Kendall B., Chakravarti A., Kendall E., Soykan I., McCallum R.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, cilt.11, sa.2, ss.381-385, 1997 (SCI-Expanded) identifier identifier identifier

Özet

Background: Chronic symptomatic gastroparesis occurs in 3-5% of patients following vagotomy and antrectomy. Erythromycin, a macrolide antibiotic, improves gastric emptying in patients with idiopathic and diabetic gastroparesis, Erythromycin's effect on gastric emptying in patients with post-vagotomy-antrectomy gastroparesis is unknown, The aim of this study was to determine if a single dose of intravenous erythromycin (1 mg/kg or 6 mg/kg) accelerates solid meal gastric emptying in patients with chronic symptomatic post-vagotomy-antrectomy gastroparesis.