Postmastectomy radiation therapy in locally advanced breast cancer

Yavas G., Yavas C., AKYÜREK S.

Experimental Oncology, cilt.35, sa.4, ss.258-266, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 35 Sayı: 4
  • Basım Tarihi: 2013
  • Dergi Adı: Experimental Oncology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.258-266
  • Anahtar Kelimeler: Breast cancer, Locally advanced, Radiotherapy.
  • Ankara Üniversitesi Adresli: Evet

Özet

Despite wide efforts for early detection of breast cancer using screening mammography, locally advanced breast carcinomas account for a remarkable proportion of all breast carcinomas, particularly in developing countries. Locally advanced breast cancer may have widely different clinical and biological features. Radiotherapy plays an important role in the management of locally advanced breast cancer. Postmastectomy radiotherapy has been shown to significantly reduce the risk of loco-regional failure and to improve disease free survival as well as overall survival in high-risk women with breast cancer. This review article summarizes the data from randomized trials revealing a significant benefit from postmastectomy radiation therapy in patients with locally advanced disease. Copyright © Experimental Oncology, 2013.