Novel pyridine-derived platinum complexes

Kutlu E., EMEN F. M., KISMALI G., Kilic D., DEMİRDÖĞEN R. E.

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, vol.138, no.1, pp.297-307, 2019 (SCI-Expanded, Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 138 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.1007/s10973-019-08242-4
  • Journal Name: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.297-307
  • Keywords: Metal halide complexes, Apoptosis, Colon cancer, Cell death, DLD-1, Cytotoxic effect, DECOMPOSITION KINETICS, THERMAL-DECOMPOSITION, ANTITUMOR, CANCER, TRANS-BIS(SALICYLALDOXIMATO)COPPER(II)
  • Ankara University Affiliated: Yes

Abstract

Pyridine-derived platinum(II) complexes with the general formula [PtCl2L2] (L-1: 3,5-dimethylpyridine, L-2: 2-amino-5-bromopyridine, L-3: 4-(4-nitrobenzyl)pyridine) were synthesized. Characterization of the synthesized complexes was made via FT-IR, UV-Vis, H-1-NMR and C-13-NMR techniques. While the thermal behavior of the complexes was investigated via DTA/TG combined system, their kinetic parameters were investigated by using Flynn-Wall-Ozawa (FWO) and KissingerAkahira-Sunose (KAS) methods. The activation energy of the decomposition kinetics of the complexes was calculated to be 196.5-31.7 kJ mol(-1) for FWO and 203.4-29.2 kJ mol(-1) for KAS. The cytotoxic effect of the complexes against the colon cancer cell line (DLD-1), which is one of the most common types of cancer observed both in humans and animals, was investigated. The complexes showed high cytotoxicity on DLD-1. In particular, [PtCl2L21] complex was found to be the most effective compounds against colon cancer cell line during the 24 h incubation period. According to these results, the pyridine-derived platinum(II) complexes would contribute to oncologic treatment as chemotherapeutic agents.