In vitro and in vivo inhibition of myeloperoxidase with 5-fluorouracil
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, cilt.57, sa.9, ss.631-636, 2001 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 57 Sayı: 9
- Basım Tarihi: 2001
- Doi Numarası: 10.1007/s002280100352
- Dergi Adı: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.631-636
- Anahtar Kelimeler: myeloperoxidase, 5-fluorouracil, myelosuppression, PHASE-II TRIAL, POLYMORPHONUCLEAR LEUKOCYTES, COLORECTAL-CANCER, FOLINIC ACID, CHEMOTHERAPY, NEUTROPHIL, FLUOROURACIL, RECRUITMENT, PEROXIDASE, LEUCOVORIN
- Ankara Üniversitesi Adresli: Evet
Özet
Objective: Myeloperoxidase (MPO) exists in neutrophils and has an important bactericidal role. During phagocytosis, MPO catalyzes a peroxidative reaction using chloride ion and hydrogen peroxide (H2O2) as substrate. The aim of the present study was to investigate whether 5-fluorouracil (5-FU), a chemotherapeutic agent, has a direct inhibitory effect on MPO and to evaluate some properties of this inhibition.