Research Information System
Acta Pharmaceutica Turcica, vol.39, no.2, pp.81-83, 1997 (Scopus)
Diabetes mellitus is associated with changes in gastrointestinal motility. The effects of experimental diabetes, induced by streptozotocin administration to rats 8 weeks previously, on the adenosine and adenosine 5'- triphosphate-mediated relaxation of the duodeniun have now been investigated. Relaxant responses to adenosine and ATP were also reduced by diabetes. A defect in the intestinal purinergic innervation could thus contribute to the motility dysfunction observed in diabetes.