Impairment of both adenosine 5'-triphosphate and adenosine mediated relaxations of rat isolated duodenum by experimental diabetes

GÜR S.

Acta Pharmaceutica Turcica, cilt.39, sa.2, ss.81-83, 1997 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 2
  • Basım Tarihi: 1997
  • Dergi Adı: Acta Pharmaceutica Turcica
  • Derginin Tarandığı İndeksler: Scopus, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.81-83
  • Anahtar Kelimeler: Adenosine, ATP, Diabetic rats, Duodenum
  • Ankara Üniversitesi Adresli: Evet

Özet

Diabetes mellitus is associated with changes in gastrointestinal motility. The effects of experimental diabetes, induced by streptozotocin administration to rats 8 weeks previously, on the adenosine and adenosine 5'- triphosphate-mediated relaxation of the duodeniun have now been investigated. Relaxant responses to adenosine and ATP were also reduced by diabetes. A defect in the intestinal purinergic innervation could thus contribute to the motility dysfunction observed in diabetes.