Impairment of both adenosine 5'-triphosphate and adenosine mediated relaxations of rat isolated duodenum by experimental diabetes
Acta Pharmaceutica Turcica, cilt.39, sa.2, ss.81-83, 1997 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 2
- Basım Tarihi: 1997
- Dergi Adı: Acta Pharmaceutica Turcica
- Derginin Tarandığı İndeksler: Scopus, International Pharmaceutical Abstracts
- Sayfa Sayıları: ss.81-83
- Anahtar Kelimeler: Adenosine, ATP, Diabetic rats, Duodenum
- Ankara Üniversitesi Adresli: Evet
Özet
Diabetes mellitus is associated with changes in gastrointestinal motility. The effects of experimental diabetes, induced by streptozotocin administration to rats 8 weeks previously, on the adenosine and adenosine 5'- triphosphate-mediated relaxation of the duodeniun have now been investigated. Relaxant responses to adenosine and ATP were also reduced by diabetes. A defect in the intestinal purinergic innervation could thus contribute to the motility dysfunction observed in diabetes.