The effects of metallothionein 2A polymorphism on lead metabolism: are pregnant women with a heterozygote genotype for metallothionein 2A polymorphism and their newborns at risk of having higher blood lead levels?

TEKİN D., Kayaalti Z., Soylemezoglu T.

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, vol.85, no.6, pp.631-637, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 85 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1007/s00420-011-0711-y
  • Journal Name: INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.631-637
  • Keywords: Metallothionein 2A, Lead intoxication, Gene polymorphism, PCR-RFLP, Neurotoxicity, CORD BLOOD, SINGLE-NUCLEOTIDE, UMBILICAL-CORD, EXPOSURE, CHILDREN, CADMIUM, SENSITIVITY, PROTEIN, ZINC
  • Ankara University Affiliated: Yes

Abstract

Numerous studies indicate that certain genetic polymorphisms modify lead toxicokinetics. Metallothioneins are protective against the toxicity of many metals, including lead. The aim of this study was to determine whether the maternal metallothionein 2A (MT2A) -5 A/G single-nucleotide polymorphism is related to the lead levels in maternal blood, placental tissue and cord blood in 91 pregnant women and their newborns.