‘‘Clinical Management of Acute Mastoiditis in a Pediatric Patient with Leukocyte Adhesion Deficiency’’
Journal of Otology, cilt.20, sa.2, ss.127-132, 2025 (ESCI, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 20 Sayı: 2
- Basım Tarihi: 2025
- Doi Numarası: 10.26599/joto.2025.9540019
- Dergi Adı: Journal of Otology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.127-132
- Anahtar Kelimeler: Acute Mastoiditis, Immunodeficiency, Leukocyte Adhesion Defect, Mastoidectomy
- Ankara Üniversitesi Adresli: Evet
Özet
Leukocyte adhesion deficiency type-1 is frequently associated with otorhinolaryngological manifestations, most notably a high prevalence of otitis media. Although multiple case reports have documented an increased prevalence of acute otitis media and mastoiditis in patients with LAD-1, no clinical or experimental studies have fully elucidated the pathophysiological mechanisms underlying this association. Despite guideline recommendations for urgent antibiotic therapy in immunocompromised patients with acute otitis media, a standardized treatment protocol for its complications remains lacking. Moreover, no established consensus exists regarding the optimal therapeutic approach for Leukocyte adhesion deficiency type-1 associated cases.This report contributes to the scarce literature on acute mastoiditis in LAD-1 and underscores the need for a tailored, multidisciplinary approach. In the absence of standardized treatment protocols, further research is crucial to refine management strategies and improve outcomes in immunocompromised patients with acute otitis media complications.