Inhibitory effect of some new diarylamine derivatives on calmodulin activity

Nebioglu D., AKTAN F., Altuntas G., GÖKER A. H.

Gazi Universitesi Eczacilik Fakultesi Dergisi, cilt.11, sa.1, ss.73-82, 1994 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 1
  • Basım Tarihi: 1994
  • Dergi Adı: Gazi Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.73-82
  • Anahtar Kelimeler: antiinflammatory activity, Calmodulin, cAMP-Phosphodiesterase, diclofenac
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, a series of new amide analogues of normeclofenamic acid were prepared and their ability to inhibit Calmodulin (CaM) dependent activity were tested. CaM-dependent cAMP-Phosphodiesterase (cAMP-PDE) was used for the inhibition assay. The results suggested that the analogues possessing dialkylaminoalkyl group have ability to inhibit Calmodulin activity as much as parent compound. Therefore, the prepared compounds would be considered prodrug of this potent antiinflammatory agent with reduced gastric mucosal erosion.