Synthesis & Anticancer Evaluation of New Substituted 2-(3,4-Dimethoxyphenyl)benzazoles

Karaaslan C., DUYDU Y., ÜSTÜNDAĞ A., YALÇIN C. Ö., KAŞKATEPE B., GÖKER A. H.

MEDICINAL CHEMISTRY, cilt.15, sa.3, ss.287-297, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1573406414666180711130012
  • Dergi Adı: MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.287-297
  • Anahtar Kelimeler: 3,4-Dimethoxyphenyl, NOESY, 1H-benzimidazole, imidazopyridine, benzoxazole, benzothiazole, ONE-POT SYNTHESIS, ANTITUMOR BENZOTHIAZOLES, ANTIMICROBIAL ACTIVITY, INHIBITORY-ACTIVITY, BENZIMIDAZOLES, CATALYST
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: The benzazole nucleus is found in many promising small molecules such as anticancer and antibacterial agents. Bendamustine (Alkylating agent), Nocodazole (Mitotic inhibitor), Veliparib (PARP inhibitor), and Glasdegib (SMO inhibitor) are being clinically used as anticancer therapeutic which bear benzimidazole moiety. Based on the principle of bioisosterism, in the present work, 23 compounds belonging to 2-(3,4-dimethoxyphenyl)benzazoles and imidazopyridine series were synthesized and evaluated for their anticancer and antimicrobial activities.