Solation of chelidonine as an analgesic compound from Chelidonium majus L.
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.38, sa.1, ss.9-16, 2009 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 38 Sayı: 1
- Basım Tarihi: 2009
- Doi Numarası: 10.1501/eczfak_0000000513
- Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.9-16
- Anahtar Kelimeler: Analgesic activity, Chelidonine, Chelidonium majus, Papaveraceae, Tail-flick test
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Üniversitesi Adresli: Evet
Özet
In this study the analgesic activity of chelidonine which was isolated from the aerial parts of Chelidonium majus (Papaveraceae), was investigated by using tail-flick test. Chelidonine is one of the main alkaloid in the aerial parts of C. majus. Isolation of chelidonine was performed by using chromatographic techniques. Spectroscopic (1H-NMR, 13C-NMR) and physical (melting point) methods were used for structure elucidation of the isolated compound. Analgesic activity of the compound was evaluated by using tail-flick test on mice at 5 mg/kg dose. Chelidonine produced higher analgesic activity than aspirine at 90th minute. However equivalent analgesic activity to aspirine was observed at 150th minute with chelidonine treatment.