Solation of chelidonine as an analgesic compound from Chelidonium majus L.

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SALTAN İŞCAN H. G., Özbek H., BAHADIR ACIKARA Ö., Baitz Gacs E.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.38, sa.1, ss.9-16, 2009 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1501/eczfak_0000000513
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.9-16
  • Anahtar Kelimeler: Analgesic activity, Chelidonine, Chelidonium majus, Papaveraceae, Tail-flick test
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study the analgesic activity of chelidonine which was isolated from the aerial parts of Chelidonium majus (Papaveraceae), was investigated by using tail-flick test. Chelidonine is one of the main alkaloid in the aerial parts of C. majus. Isolation of chelidonine was performed by using chromatographic techniques. Spectroscopic (1H-NMR, 13C-NMR) and physical (melting point) methods were used for structure elucidation of the isolated compound. Analgesic activity of the compound was evaluated by using tail-flick test on mice at 5 mg/kg dose. Chelidonine produced higher analgesic activity than aspirine at 90th minute. However equivalent analgesic activity to aspirine was observed at 150th minute with chelidonine treatment.